1 Up - states are Rare in Awake Auditory 1 Cortex
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چکیده
18 The dynamics of subthreshold membrane potential provide insight into the 19 organization of activity in neural circuits. In many brain areas membrane potential is 20 bistable, transiting between a relatively hyperpolarized down-state and a depolarized 21 up-state. These up and down-states, which have been proposed to play a number of 22 computational roles, have mainly been studied in anesthetized and in-vitro 23 preparations. Here we have used intracellular recordings to characterize the dynamics 24 of membrane potential in the auditory cortex of awake rats. We find that long 25 up-states are rare in the awake auditory cortex, with only 0.4 % of up-states longer 26 than 500 ms. Most neurons displayed only brief up-states (bumps) and spent on 27 average about 1 % of recording time in up-states longer than 500 ms. We suggest that 28 Articles in PresS. J Neurophysiol (January 23, 2013). doi:10.1152/jn.00600.2012 Copyright © 2013 by the American Physiological Society. 2 the near absence of long up-states in awake auditory cortex may reflect an adaptation 29 to the rapid processing of auditory stimuli. 30
منابع مشابه
Up states are rare in awake auditory cortex.
The dynamics of subthreshold membrane potential provide insight into the organization of activity in neural circuits. In many brain areas, membrane potential is bistable, transiting between a relatively hyperpolarized down state and a depolarized up state. These up and down states, which have been proposed to play a number of computational roles, have mainly been studied in anesthetized and in ...
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